Plasma Neutralization of the SARS-CoV-2 Omicron Variant

Summary: >Although these findings indicate that the omicron variant shows an unprecedented degree of neutralizing antibody escape, they also suggest that boosting and promoting affinity maturation of antibodies in persons who have previously been infected or vaccinated with the use of existing Wuhan-hu-1–based vaccine immunogens, will provide additional protection against infection with the omicron variant and subsequent disease

>For those who had received two doses of an mRNA vaccine approximately 6 months earlier and then received a third dose of an mRNA vaccine approximately 1 month before sampling, the NT50 values after the booster dose were 26 times greater for Wuhan-hu-1, 35 times greater for PMS20, and 38 times greater for omicron