- the docking adapter discussed in the answer did not make it. However, the answer offers a couple of alternatives, so +1.
- they painted some crosses on the JWST to make alignment easier.
- JWST's L2 location is really far from Earth. It's about 4X the distance from the moon. So a manned mission is currently infeasible. But maybe in the future.
- while fueling may be possible, any other sort of maintenance probably isn't. To save weight, the JWST is mostly glued together, unlike Hubble which used spacesuit accessible bolts.
A complicated sunshield deployment seems somewhat inevitable, personally, but I'd be happy to be proven wrong there.
Given the increased interest in manned missions and recent technology advancements/investments, I wouldn't be surprised if we could get there in 15-20 years, which sounds likely to be when it'd need to be refueled.
If it's worth it or too dangerous to send an astronaut to deal with the dangerous refueling operation are whole other questions. But actually getting there? I think we can do it in 15-20 years.
Like, serious question: how much cost are the raw materials for the fuel and spacecraft/rocket, and how much are the costs like human labor and ground transportation to the launch site?