Pre-covid, most people were around multiple other people for most of their waking life. I don’t think it’s at all surprising that a mode of working where you spend every working day without seeing another human is causing some people difficulty.
It is hardly fair to expect people, especially who dont want it themselves people or aren't even friends with to not work from home for such reasons. Though it may well be that many introverts need on this more than extroverts, despite often wanting remote. My point is that leadership is primarily ensuring a social environment where people work well, and the ones who figure this out will benefit greatly.
Our company also is on the older side (in longevity), even though we're a small business the company has a lot of systems in place that's not equipped for remote work. I'm really trying to change this since I firmly believe hybrid seems to be the way to go moving forward.