Limitations: We hypothesize that the healthier metabolic profile observed in homozygous c.273_274delAG carriers was mediated by acetate produced by gut bacteria; however, we lack data to firmly verify this hypothesis.
Impact: Our results suggest that sucrase-isomaltase constitutes a promising drug target for improvement of metabolic health, and in a broader perspective add to the debate about the health effects of sugar consumption.
You know, it could be that these people are healthier because they avoid sugar because sugar makes them feel like crap when they get overloaded with aceatate.
There is no evidence that higher levels of acetate are better for people. Because if that as so drinking would be healthy for everyone.
https://academic.oup.com/alcalc/article-abstract/23/2/123/96...
https://www.biorxiv.org/content/10.1101/2020.07.20.212597v1....