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Comment by chana_masala | Hacker News Reader

And 4 doses for the coming Sigma variant? It seems never ending with these leaky vaccines

> And 4 doses for the coming Sigma variant? It seems never ending with these leaky vaccines

On the other hand, these "leaky vaccines" have already prevented a massive amount of mortality. Yes, the duration and quality of protection, even boosted, against Omicron is unfortunate... but even 2 doses can still be expected to save a high number of lives from Omicron.

I doubt that in the long term. The long term health effects of the vaccine are largely unknown but already looking grim.

> The long term health effects of the vaccine are largely unknown but already looking grim

This is not supported by any evidence.

Not longer term if they end up creating hotter variants through vaccine escape. Look into OAS, I think it's a good thing the latest variant came from Africa and not Israel

Great point regarding Africa vs hypervaccinated Israel. However I am unfamiliar with what you mean by OAS.

Original Antigenic Sin. See here: https://pubmed.ncbi.nlm.nih.gov/28479213/

Here's also some analysis about this effect with Omicron, which seems honest about the limitations: https://boriquagato.substack.com/p/theres-something-antigeni...

Ah great, thank you for sharing!

Wait until you see how many doses people need for tetanus, pertussis, and diphtheria

(4 in 18 months with boosters every decade)

Wait until you see how bad the pertussis vaccine is at protecting against whooping cough!

Are you up to date on your boosters for DPT? I don't know anyone who has maintained that.

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