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It's something I have seen a lot of people say here on HN, but I don't know if it's true. If having the whole virus was more effective than just the spike protein, wouldn't Sinopharm and Sinovac—which are inactivated virus vaccines—be more effective than Pfizer and Moderna? We still don't know their efficacy against Omicron, but they were less effective than mRNA vaccines against all previous variants.

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Initially perhaps, but do we have good longer term data on how the sinovac holds up, given we're now saying Pfizer needs to be 3-monthly and Moderna is a much stronger dose? I think there was some over-selling of the mRNA vaccines that needs strong follow-up review given the state of the virus vs last year without vaccines with a more potent variant.

We won't have long-term data until a long time had passed, but so far, it doesn't seem inactivated virus vaccines fare any better than mRNA ones.

https://www.nature.com/articles/d41586-021-02796-w

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