So you like typing more and making your program harder to read to avoid using two apostrophes and two commas.
I’ve seen bugs where some forgot to add quotes and commas to split some arguments and the program did the wrong thing. Parent’s approach avoids that. However, things like spaces in quoted strings are not correctly handled.
I assume you meant something like subprocess.run(['mkdir', '-p', '--', *path.split()]), which in that case using shlex.split will fix your problems with quoted strings.