I guess yes I do, although I've never really been that bothered by syntax highlighting, so I don't use it as much as most. When I do use it, it'll be subtle e.g. change from black to dark blue, or similar. But I also do a lot of my work in the shell, and while I like colour in things like a git diff, I don't care either way for syntax highlighting in code other than liking a grey for comments so it doesn't draw my attention away from the code.

However, actually I guess even syntax highlighting doesn't make too much difference if your background colour is black or white, because that still works well for mapping into YUV where the chrominance can be whatever the syntax highlighting is using and the background is either full brightness (white) or no brightness (black). Even black on white with red underlining can be done with the same chrominance.

The real problem, and what I really meant, is when you have things with e.g. red text on a green background, which just turns into an illegible mess when using YUV 420 (also my bad, the monitor actually does 420 not 422) because the chrominance is different, but the intensity is approximately equal.

So, for almost everything it works well. Youtube videos, code editing, text editing, etc. are all fine, but for some pathological use cases it looks terrible.

I’ve experimented with this a few times. I find at least some degree of color and style differentiation helps (e.g., comments, string constants). For this I liked the Tao themes for emacs. It was completely fine. I moved back to various color themes just as a change of pace, like changing the wallpaper.