Well, that's a one way to say it for sure, but that's almost the most delicate way, lol.
Well, that's a one way to say it for sure, but that's almost the most delicate way, lol.
I am pretty sure that "мне по хрену" is a parody on "мне по плечу" (literally "fits my shoulder" but means "doable to me / within my powers"). Russian people coin new expressions with such witticisms all the time.
So, reproducing the same parody in English, one could say "fits my wiener". Horseradish here being an obscenity-avoiding euphemism for c*ck (like English "wiener"), not the plant (just like all the sausages and cucumbers in the other languages).
As I native, I would assume that "мне по хрену"/"мне похрен" is an euphemism of the more rough variant "мне похуй" (it is up to my dick, same height as my dick).
The story goes that it came from chemistry, where a litmus paper is purple in a neutral liquid, so a person does not react in any way.
For general absence of fucks, there's also the suitable ‘it doesn't fuck me’.
«На хую вертел» is one of the multiple creative ways to express «don't give a flying fig about something».