So if you hit next, next, next you'll lose: Google Safebrowsing (security), malware scan (security), DNS over HTTPS (security and sometimes functionality), Automatic Browser Updates, access to content that requires Widevine, all third-party cookies-based authentication, anything that relies on referers, anything that relies on IndexDB, anything that relies on extended session info, anything that uses WebGL or WebRTC or WebAudio, et al.
As I said, I like the design, but the current defaults get 0/10 from me. Simply awful. If use the default profile here your browsing experience will be objectively worse and less secure.