In theory, any framework that follows the WSGI guidelines should be able to run on top of FastWSGI and take advantage of its speed.

There are many frameworks out there. I do intend to test out some more. For now I've only tested the popular Flask framework and a simple bare bones WSGI app.

Flask was never developed to be lightning fast. Even still, I am quite surprised at how slow it is now that I've seen what kind of numbers can be achieved. I haven't looked deep into it to see where the issues might be.

As for security, that is a work in progress... I definitely wouldn't use FastWSGI in production in the projects current state. It's still early days in terms of development.