A self-sufficient base in Arizona is beyond our current capability. Good luck with Mars.
Mars will be thousands of times harder, with correspondingly-many likely-fatal lessons. Anybody who doubts that even a little is not somebody you want on the project.
I don’t think thousands of times harder rings true, conditioned on having accessible shipments of new goods. On a slow but regular scale. A colony wouldn’t even need to be self sufficient. Just protected from the elements.
I have no doubt it’s very difficult, but thousands of times harder? Seems extreme to me.
Anybody useful would be able to list dozens of debilitating problems to prevent before even starting research.
Oxygen? Send a fuck ton of the candles they burn on nuclear subs
Food? Send a fuck ton of food
Water? Probably better ways to do this but, fuck it, send a fuck ton of water.
Power? Send them a bunch of solar panels and batteries. 100x daily needs.
Shelter from radiation temperature and weather? Go sit in the starships. Stack them together. They’re not going anywhere. Send 50x the space suits. 50x the rovers. 50x the fruit loops.
The hard part of colonizing a planet is the self sufficiency. If you can just keep the supplies coming then it’s not all that different from the ISS. You can try and build your moxie units if you want, or your Martian farms, or whatever, but there’s not much in the way of mission critical goals. Mars’ dust storms aren’t nudging the starship heavy.
They tried to use the Sabatier process on the ISS, and it failed for unpredicted reasons.
So, again, you and everybody who thinks like you would be bad choices to have involved.
[1] https://www.youtube.com/watch?v=7XdkKMhAdnA&t=458s (Neil deGrasse Tyson)