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Yes, that's what we use. We initially planned it as a multiplatform approach, but on Mac we went native. We routinely get complaints about the app being old school and "ugly", but on the flip side, we didn't have to learn C#.

Yes, as long as you have visual studio installed it is quite seamless. I have taken huge GUI apps targeting Linux and had them “just work” on windows. On that note, I’ve taken GUI apps targeting Linux and cross compiled them to android and it “just works.”

Edit: wasm as well. I just started messing around with emscripten and it blows my mind that I can run a qt GUI app in my browser.

I know. This is what windows need to learn from *nix.

qmake and QtCreator work great on Windows and Mac. QtCreator calls the command line version of Visual Studio on Windows. The QtCreator debugger works seemlessly. (NB/ I'm still on Qt 5)