Since handwriting is not as widely used I'm less troubled by being left-handed. It was always a deal that my hand would smear ink and pencil as I wrote. I never learned to hook write so my hand always slides right over my writing. Now I barely write anything more than my signature these days.
I only eat/cook and write left handed - I'm right handed for everything else so I'm perhaps not typical. Eating as a lefty can be problematic because I always grab the wrong drinking glass. However I eat European style with my knife in my right hand and I don't need to switch hands with my fork - I enjoy that.
Not sure if full lefties have this issue but I often have directional issues with right/left commands. I will often turn the opposite direction from the commanded direction. This was really tough while I was training for Marshall Arts. It also happens if someone is directing me while driving and I often have to ask several times to be sure I'm going to turn in the correct direction. People think this is charming but I don't.
Other than that it's hard to find a good/affordable Japanese left handed knife. First world problems I assume. Plus some mobile software is primarily right handed and isn't easy to use if you're holding your phone or tablet with your left hand.