Alternatively, pyenv and pyenv-virtualenv for shell integration and seamless virtualenv activation.

To be fair, I'm not saying there's anything wrong with virtualenvwrapper, just that I've never used it and for my purposes the above solution works well.

That's been my thing, but I do nothing of interest.

Maybe 3.11 can make python packaging less of a beautiful disaster.

This doesn’t solve dependency management? All it does is it separates your env and you can install what you need there. But installing with pip is still subject to version incompatibility etc.

Just go docker