Viagra Is Linked to Almost 70% Lower Risk of Alzheimer's
sciencealert.com
sciencealert.com
That of course is not proof of a causal link, but it's enough to justify follow up research.
What would be interesting would be a comparison again Cialis (the competitor to Viagra).
Especially given the size of the effect combined with the known interactions between Viagra and Tau proteins.
A comparison with Cialis might well be worth it down the line, but I don't see what it'd give before they've established whether or not there's a causal link.
Or money.
My grandpa whom I've never caught lying, told me that in WW2 Romania, as a very young conscript, he was given a medical examination... consisting of the nurse fondling his junk. Apparently they decided very fast he was healthy and the same for every other conscript, except for the only son of an aristocrat(most were tough peasants such as my grandpa) who would not get an errection.
A couple of weeks later, that young man who did not pass the "physical exam" got really ill and only my grandpa took pitty enough to carry him on his back to a hospital, where they guy died a couple of days later.
Also doesn’t tadalafil act for 36 or something like that hours?
https://www.sciencemediacentre.org/expert-reaction-to-study-...
> Sildenafil is more often prescribed to wealthy people and low socioeconomic status is associated with higher risk of Alzheimer’s.
> There are other possible explanations for these findings; for example, we know that brain changes start decades before dementia symptoms and it is possible that these early Alzheimer’s changes reduce sex drive (thus people wouldn’t ask for a prescription for erectile dysfunction). [...] They did try to control for this by looking into patients with pulmonary hypertension, which is sometimes treated with sildenafil. However, this group did not have a statistically significant decreased risk in Alzheimer’s disease.
> people who take sildenafil have less serious cardiovascular damage than those who are taking the other drugs to combat hypertension or diabetes. If cardiovascular damage is a key causal factor in developing Alzheimer’s disease, then these people might anyway be at an advantage compared to people who have to take drugs for hypertension, cardiovascular disease or diabetes. The study tried to control for this, but it is not clear if severity of the different conditions controlled for could be taken into account (those with more severe hypertension are presumably more likely to be taking anti-hypertensive medication such as losartan).
Many of the opinions are quite positive though, and praise the high sophistication of the statistical methods.
I'm curious to know if there is any info related to alzheimers and sex drive. The 70% is based on chance developing alzheimers in the next six years, I wonder if there is any relation between a profile who would seek Viagra - I guess that would be people interested in sex, have an available partner, but having trouble - and one who would be less likely to get alzheimers soon.
But very frequently when he was on the toilet he would play with his erm... sword and unsheathe it (Easter Europe, I'm cut, he wasn't) and his wife asked me why he did that?
And I was like.... "erm.... I think that question is overdue by about 40 years.."
I find it somewhat hilarious to think that soon the Covid vaccine infomercials might be extended with "To keep you safe also remember to have sex" .
The link talks about 70% decrease of Alzheimer risk over a 6 year period of Viagra use (vs lack thereof).
But early Alzheimer signs have been shown to appear up to 18 years before diagnosis. Memory and thinking tests for these signs from 13 to 18 years before diagnosis show 85% higher risk in those failing. [0]
So 6 years is actually a very short window to claim causality, especially when it can be guessed through other means with (my guess) higher accuracy.
[0] https://www.alzheimers.org.uk/research/care-and-cure-researc...
They're not claiming causality.
-While maintaining a safe distance, mind.
> * Choose sexual positions that limit face-to-face contact.
> * Use barriers, like walls (e.g., glory holes), that allow for sexual contact but prevent close face-to-face contact.
> during sex ... consider keeping contact information for your partner(s) so that
> you can reach them if one of you develops symptoms.> When supplying fee-based sexual services, practices carried out close to the face are not permitted. (and a bunch more rules)
Viagra increases testosterone?
I wonder if this relates to other things that increase late-life testosterone like red meat (unprocessed)?
https://www.alzdiscovery.org/cognitive-vitality/blog/does-ea...
I've always thought about how big of a role testosterone plays in later-life health and I wonder why doctors don't prescribe it to restore testosterone levels to a normal (for a younger person) level to prevent osteoporosis and other hormone-linked diseases. Not saying this conclusion in the article is related to testosterone, but I have to speculate on it.
And most of the apparent benefits of testosterone look to be more correlational than causational. (except osteoporosis, and sarcopenia)
there are some doctors who prescribe test to keep patients test level up later in life, but the increased quality of life might mean a decreased life span and not everyone is willing to take the trade-off.
patients willing to try usually just try a few doctors until they find one who does.
1. The effect is huge.
2. Phospodiesterase is heavily expressed in neural and glial cells
3. There are a ton of alzheimers rodent RCTs with positive results.
Of all the studies I've seen recently, this one scream Correlation != Causation.
"Notably, we found that sildenafil use reduced the likelihood of Alzheimer's in individuals with coronary artery disease, hypertension, and type 2 diabetes,..."
Another reality is that death, old age(and sickness with it) strikes such fear into people's hearts that they are willing to walk around with perpetual erections to prevent Alzheimer's disease(and the absurdity of my comment is linked to the absurdity of the click-bait title)
Lots of people suggesting having sex might be a prophylactic but also consider that a lower "sex drive" might also be a factor here.
We don't know because we're looking at insurance claim data. You only see links. And only in people with insurance! You have to go much further to show causation.
Sex/touch just felt incredible as a teenager, when I could not control neither erections nor orgasm. I remember dancing with this girl in 8th grade, she had a green silk dress cut in the middle and she put her leg between mine, to this day I remember how that felt; once I was able to control erections/orgasm, it felt like I severed 80% of naughty tough sensations somewhere in in my brain.
I guess once you can control something, some magic is lost.
If you do think everyone is popping these, I'd suggest this is maybe a side effect of years of being exposed to too much spam and way too much under-regulated pharmaceutical advertising. They're not without unwanted side effects, and again, don't overcome a disinterest in sex.
If they wanna prove it's thanks to viagra they should find people who don't have sex, take viagra and have lower risk of developing Alzheimers.
It's the same sort of reasoning why ageless musical hits are still enjoyed today. The musical hits that aged poorly have been forgotten over time.
It's not that old stuff was better, it's that modern stuff hasn't had enough time for the crap to be forgotten.
https://www.reuters.com/article/us-southkorea-politics-viagr...
The significance of that data is up for interpretation, but I'm skeptical that sex is really a significant cardio activity.
Jokes aside, isn't 90s is good enough? What's your normal one and high one after exercise? I honestly never measure.
60 - awake resting
90-110 - walking, carrying things
120 - light aerobic exercise
130-150+ - a good workout
Either you're an elite athlete with a low resting heart rate or your girlfriends heart rate gets signifincally higher than yours :)
I'd be happy to tell you that I never wear a watch to bed, but that is in part because I don't have a watch.
I don't have data, but I would bet $ that sex is much more beneficial for overall health & wellbeing than exercises resulting in a similar heart rate.
Furthermore, sex is likely to indicate that someone has a loved one (connection, meaning, social life in general).
Is it possible that usage of viagra indicates an interest in/ability to participate in sexual activity which also indicates a level of health and mental acuity that would be less common among those with Alzheimer's?
Another trick is to form a fist and put it between your legs at your knees and squeeze your legs as hard as you can trying to crush your fist. You might feel a slight pop and things should work better after a few seconds of squeezing your fist.