I know very successful people who are miserable, stressed-out workaholics. And I know very successful people who could have been one of the people strolling around Sebastian when he was writing this post. I know people who run startups from their home office and take their kids to school in the morning. Hell, look at Sebastian's own situation: he apparently has enough time to sit and pontificate for a couple hours on a train platform in Japan, in the middle of the day. He can't be working THAT hard :) Maybe what he's trying to say is that you can't have the idyllic suburban family life if you want to float around the world living off of random consulting gigs? But there are probably quite a few very successful people here on HN that live relatively idyllic family lives in cities and suburbs all over the world.
I think the idea of feeling isolated for being very ambitious is true, but I would caution Sebastian and others against the idea that you have to sacrifice your connection to a community, your face-to-face relationships, your health, and your overall happiness on the alter of amassing $40m for an amorphous purpose like being able to build a shrine with 5% of your wealth or less. You certainly can sacrifice all those things, but most people will never amass $40m no matter what they sacrifice. Better to find something (and someone) that you love, work hard at it, and enjoy life. Yes, you should take chances, yes you should push yourself and be ambitious. But this is the only life you get; don't squander it living a life you don't enjoy because you're hoping for the big payoff down the road. It probably won't come.