I do, although it's slowly being replaced with PowerShell (which is more convenient for integrating with windows applications, has better pipe semantics and better management stuff, particularly WMI, deployment etc). Plus it's built in and comes with a nice IDE on Win7 (PowerShell ISE).

At the moment though, I use Python for time management (using some scripts I wrote), a general purpose calculator, data munging on the fly, watching memcache stats, reporting and some other general bits of duct tape and string.