This was my first real job after graduating, and one of my roles was industry research and putting together a weekly newsletter of interesting technology to keep an eye on and when ITA released Matrix we loved it.
Long story short, we wanted to do a lot of things like this, but our airline (and most others) were not developing our own tech and instead using some technology from the major GDS companies (Amadeus, SABRE, Galileo). One project I was on was working to try and implement just a basic fuzzy date search (eg +/- 3 days of your preferred date) and our GDS was quoting us something like $3M and 12months to deliver.
Luckily we had an exec who understood business, technology, and design and got resources to build out internal technology team and we started building our own technology that freed us from some of the constraints of GDS to great success!