Unfortunately, text-substitution macros (like CPP) pretty much force a source file to be treated as a stream of bytes. They can be handy, but delimited macros (e.g. like Lisps) are much less invasive.

Technically the parsing itself and the grammar are the same, they don't depend on defined macros. Yes, defining a macro in an included file can make the resulting AST change, but the parsing algorithm doesn't really care about it.