I've only watched the the first five minutes of that video; I think he has some fundamental misconceptions that make it difficult to take much from what he's saying.

e.g. for #2 wave/partical duality (which isn't necessarilly even a thing, depending on what foundation of QM you subscribe to) he says that everything is energy and that energy is light; this is not correct (the 2nd part)

for #3 energy is not necessarily conserved over long time frames in our universe

#4 depends on which foundation of QM you subscribe to, but doesn't necessarily require non-locality (AIUI, if your foundation results in this problem, then you must chose between locality or reality to explain things - reality in this context not really meaning what it might mean in common parlance)

#5 singularities appear in black holes because the maths breaks down because we don't have a unified theory of QM+gravity; they aren't magical. Also the big bang wasn't a singularity in the way he seems to be implying, again AIUI

I'm no expert, but I would suggest you review some more technical videos before reading too much into the link you posted (I suggest PBS Space Time / FermiLab / Sabine Hossenfelder)