I.e. try setting your mouse or keyboard to have even 50-100ms of lag, a lot of people would find that very distracting to use even for just using a terminal Emacs/Vim & for writing plain-text.
There's a reason these things are being marketed as "secondary displays", which makes perfect sense.
In terms of cost I really don't see why anyone would want to do it differently anyway. A 20" LCD is dirt-cheap these days, so if you're already spending 5x or 10x that on the same size of E-Ink display why not get both?