There are a lot of things I'm used to doing on a computer that I can't do on an iPad. Everyone has their examples of things that make X inferior to Y. Apple has shown that they can be successful by offering less of "business as usual" while slowly introducing new ways of doing things.
The only way to advance the state of the art is to let go of a lot of the notions of what we think a computer should be. Is rearranging toolbar buttons really going to bring delight to people around the world? How does this help the guy who is miserable at his job because he's forced to use a 10 year old PC running Windows XP? How does it help the person who lost all of their vacation photos because they downloaded a photo editing app that turned out to be a virus? How does it help a four year old that's learning to read?