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Replication-incompetent adenoviral vectors? Lex Fridman had a virologist on his podcast talking about the mutations done to the adenovirus to make it safe for the delivery of the s-protein (used in viral vector J&J + AstraZ vax). Maybe I misunderstood that?

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Engineered vs evolved.

For sure you can take a virus and knock out the bad bits - but I believe we have no evidence this has occurred in the wild due to selection pressure.

I’m not talking about inactivation with formaldehyde. If they did that in the viral vector it would disable the delivery mechanism (adenovirus).

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