I was on call for 5 years at an old job (non IT). Getting paged and yanked out of bed at all hours messes with you in so many ways. Being sleep deprived you turn to high sugar drinks and foods to keep you awake. The sleep deprivation and bad diets causes you to put on weight. Going to bed with the idea you could get paged does terrible things for your anxiety. On top of that all the sleep deprivation changes your personality.

You become highly irritable and it really brings down your mood. Eventually I couldn't deal with it after 5 years and I pretty much walked off the job. I didn't realize the toll it was taking on me and what being on call was doing to me until I was no longer on call.