Aside from speed, one thing that really eats at me is that it makes any sort of functional programming overly verbose, unfun, and just not very idiomatic. Also the the vast majority of python programmers simply don't understand the best practices in their own ecosystem.

I was recently writing code using Reactor/RxJava in Java 11 w/ Lombok. I don't think I've ever been so productive or lead a team as productive as when we were going ham on the functional/reactive Java. Now that I'm back in Python land, I am constantly frustrate on a daily basis with both the language and the runtime at every turn. Even with the asyncio we are working on, it feels like the absolute minimum viable product when compared to the java, node, or rust I have done.

There are some fantastic python enhancements that bridge some of the gaps like PEP 484 (Type Hints) and PEP 517 (holy crap an actual build systems that are not dogcrap) but it feels like the python community does not care.