Travel time to "home" seems close enough in terms of months long voyages. Haven't decided which journey is the more treacherous option.
The 15th century colonists came to a place that was resource rich in whatever a colony could need: food, water, building material, etc. Martian colonists will not have that luxury.
New world colonists faced an indigenous poplulation that Martian colonists won't have. Probably a good thing, as the examples provided by the new world colonists on how to interact with indeginous people does not bode well (at least for those who continued to follow).
Communication time back to home is actually in the Martian colonist's favor. As is the fact the area will have been surveyed quite exetensively in advance of arrival, so preparations can be better made with that knowledge. Full detailed maps will be available as well. This will help finding more barren wasteland even easier than just wandering around looking for barren wasetland. Effeciency will be key with the constrained resources.