If your software can run on linux it's extremely unlikely to not work on NixOS.

In fact proprietary binaries will be much easier to run since you don't have to do with non-reproducible builds in some source repo/build system.

Have you considered reading the manual? NixOS is not for you if you don't want to spend time learning the basics.

I have run xilinx vivado inside FHS within 15mins. Mostly figuring what libraries are needed for all binaries.

https://nixos.org/manual/nixpkgs/stable/#sec-fhs-environment...