Unless you get a lot of custom pieces, you can lose a lot of space or end up with awkward and ugly situations, so it really only works for people who have the time and resources to spend on custom interior design.
Because of all this, resale of the home can be difficult, because your market is limited to the small community of people
Perhaps as 3d and custom manufacturing becomes more commonplace and price competitive with assembly line products, there will be more of an appetite for the amount of customization that these kinds of homes require.