If we lock down in 2022, what's to stop another lockdown in 2024 and in 2026 etc.? Imagine the mental health implications, especially on children and teenagers, whose entire childhood would be altered by covid. Imagine "who knows if we're going to have Christmas this year? We have to see the forecast for cases and hospitalizations", every year for every special event. People will celebrate Christmas and hang out and go to huge events or they will literally go insane.
Also, there would be massive supply chain issues like you said. Possibly big enough to actually kill people. So now we have to actually weigh the casualties of lockdown vs the casualties of a virus.
It was different in 2020. The lockdown in 2020 was designed to be short-term. It was also much more serious, because we had no idea just how dangerous covid was, and we actually had a chance of eradicating the disease entirely. That's why we could shut-down schools, cancel events planned years in advance, make court appointments virtual, and otherwise significantly alter critical parts of society.
And even then, even in early 2020, there was a not-so-small vocal minority of people (idiots) who refused to believe covid existed.
That's not to say we'll do nothing and assume covid is over. I do believe society can adjust to "stay safe" in the long-term with routine vaccination, mask-wearing in public spaces, and just being aware that covid exists. Also things like WVH and online classes (for those who want to take online) are here to stay. But people are not going to follow a "new normal" where every social interaction is weighed against the virus.