Moderna has fewer breakthrough cases than Pfizer's, but higher myocarditis rates
cnbc.com
cnbc.com
At least where I am, booster doses using moderna are recommended at half doses (50mcg).
They both use the same spike protein sequence.
No idea how the excipients differ between the two, but neither has adjuvants.
https://www.nih.gov/news-events/news-releases/nih-clinical-t...
Meanwhile pfizer tested 10, 30 and 100 and ultimately settled on 30mcg as their sweet spot.
https://www.nature.com/articles/s41586-020-2639-4
Was this due to differences in the vaccine itself, different study environments, or different tolerances for the balance between side effects and effectiveness?
I don’t think we’ve done any blinded head to head studies of one vs the other.
> Symptoms can include shortness of breath, chest pain, decreased ability to exercise, and an irregular heartbeat.[1] The duration of problems can vary from hours to months.
That's the kind of thing people often ignore. Especially if it only happens once. _Especially_ when getting healthcare is expensive.
> Previous research co-authored by Balicer found that in this age group, becoming infected with SARS-CoV-2 made a person 18 times more likely to develop myocarditis — a much more significant risk than is observed following vaccination.
Sources are in the article. You can easily find sources for COVID, please try searching it yourself first.
"Healthy boys may be more likely to be admitted to hospital with a rare side-effect of the Pfizer/BioNTech Covid vaccine that causes inflammation of the heart than with Covid itself, US researchers claim."
https://www.theguardian.com/world/2021/sep/10/boys-more-at-r...
Anecdata from another thread: https://news.ycombinator.com/item?id=29122896
> Across all ages, the risk of myocarditis was almost 16 times higher for people with COVID-19 compared to those who aren’t infected. The myocarditis risk is 37 times higher for infected children under 16 years and seven times higher for infected people ages 16-39 compared to their uninfected peers.
> My understanding is that the incidence of myocarditis is much higher in a COVID infection than from any of the vaccines.
Had two vaccine shots. Both times, 10 days after the shot, my heart hurt like hell. Really painful and scary experience. It lasted a couple days and back to normal.
Sucks folks are experiencing them though. Definitely a scary time.
Don’t think I’m questioning it, I’m just surprised so I want to hear more because I thought even getting Covid twice was fairly rare, after all isn’t that a widely held conception by survivors who don’t want vaccinated.
1. Had covid early 2021, felt like a mild cold for a week, couldn't smell my farts for 3 weeks. No heart issues.
2. 8 months later, got the Pfizer double dose, and had 6 weeks of heart pain and palpitations. Finally got in to see the doctor after the pain was basically gone, and the EKG showed an irregular heart beat and I was told to go to the emergency room... Got an echocardiagram the next week which turned out normal, thankfully.
Still waiting on that $1,000+ medical bill to come in the mail for the 20 minute echocardiagram...
Any stats on how many 13-29 year olds vaccinated with Pfizer have gotten myocarditis from a breakthrough case specifically?
> Burton cited data from France on males ages 12 to 29. It showed there were 13.3 cases of myocarditis per 100,000 people for Moderna’s vaccine compared with 2.7 cases per 100,000 people for the Pfizer vaccine.
> there were 86 breakthrough cases per 100,000 people for the Moderna vaccine. That compares to 135 breakthrough cases per 100,000 for Pfizer’s, he said
Are the differences meaningful? Assuming the data is real, Pfizer does seem quite a bit safer!
Which on its own isn't too helpful but then you know that the standard deviation is equal to the square root of the average. In this case both values bracket 100 so the square root should be around 10 making this a difference of roughly 5 standard deviations.
This isn't a Gaussian distribution so the 5-sigma limit used in physics can't be applied directly, but it's still a pretty big difference, especially for medical data.
You could (and in some cases should) do the work to get a proper number for the significance but this back of the napkin estimate suggests it's a statistically meaningful difference. And this being a calculation that can be done at the top of one's head, it is useful when the news reports on a change in some statistic that isn't anywhere close to significant.
Especially when you take into account that your risk of developing myocarditis is higher if you get Covid.
You have to compare the odds of getting the vaccine (100%) AND getting myocarditis with Moderna versus the odds of being exposed to Covid AND getting a breakthrough case with Pfizer AND getting myocarditis from said breakthrough case with Pfizer since the vaccine makes the symptoms of breakthrough cases milder anyway.
The problem is that getting the vaccine is a 100% event, versus a far less than 100% event in scenario 2 (breakthrough Covid case with Pfizer that causes myocarditis in that age group specifically). Add up ALL the maths.
Edit - this isn't a vaccine versus no vaccine comparison. This is vaccine versus vaccine. Pfizer (in the current recommended dose) has proven very effective AND safer. Also, what percentage of breakthrough cases with Pfizer have resulted in myocarditis? Maybe that particular stat changes the risk profile. I'm guessing it's low though.
Edit 2 - also maybe the risks of Moderna can simply be reduced by reducing the dosage. Who knows. More testing will occur over time I'm sure.
At this point my conclusion is that everyone either get
- the vaccine,
- the vaccine and covid
- or covid without the vaccine
- or just covid
within the next couple of years unless they live outside of society.
I see no way an ordinary unvaccinated person can avoid catching covid now except using extremely much more invasive countermeasures than the vaccine.
But I might have missed something. How do you suggest people avoid it?
(Just theoretical interest. I took the vaccine as soon as it was clear that those charge took it themselves ;-)
Read my post again. I specifically said I'm comparing vaccines, not comparing vaccine to no-vaccine.
Don't try to argue a strawman.
Pfizer prevents enough infections that the risk of a breakthrough case is low. Plus the risk of getting exposed to Covid over any given time period is less than 1, even if it's 1 over a long enough time period. It's also a low enough risk for the age group being discussed that they can take the time to make an informed choice of Pfizer vs. Moderna.
But that's just a case of 1. How severe is the myocarditis other people experience? According to a study I just googled [1], out of 2 million people, only 32 were hospitalized with myocarditis or pericarditis, with median hospitalization time of 1 to 2 days, no ICU, and no deaths. Doesn't sound so bad to me.
[1] https://jamanetwork.com/journals/jama/fullarticle/2782900
have you seen the new psyop where vaccine holdouts now get the shot but believe they can quickly remove it, similar to reacting to venom? I’ve been starting to think of things like that at their level of comprehension. I’m getting better at it. Will be procedurally generating this benign nonsense soon.
I started noticing someone was already doing it after the prior psyop was so obvious. Many anti vaxxers began believing could only avoid “shedded spike proteins of the vaccinated” by social distancing and masking up forever. Ironically gaining compliance with all guidelines but in a way they believed was original and never having to argue with them ever.
Got to think like them! Similar to what comedians do.
I'm not saying I agree or disagree with anything you're saying here, but more and more I wish I had some kind of debugger that I could run on internet comments, and it would show me all of the inputs that a commenter saw that led to the comment in question. All the various social media threads, conversations with friends/family/doctors, published papers, news articles, every single input that factored into what was written.
I say this because this comment to me seems like nonsense, because it doesn't line up with any of my inputs. Which of course doesn't mean it actually is nonsense, it just looks that way to me.
I think if we had this capability, people would actually be able to understand each other. Instead we just have everyone thinking that the sum of their own inputs is the ground truth, and everyone else is a nutjob.
Without those 3 things, I think there is a good chance that you're just antagonizing someone for little benefit to you or them.
Doing a callback without offering any opinion or arguments helps them introspect about how incongruent their world is with reality.
“<person that died while with covid> was still doing research?”
“The last president didn’t get reinstated?”
“I like hooking up with antivaxxers because you only have to pay child support for 5 years instead of 18. the mom/baby will still be doing research(tm)”
[1] https://theportal.wiki/wiki/The_Distributed_Idea_Suppression...
> is there anything like Snoo for reddit that keeps track of deleted and flagged posts on HN?
Not for deleted but you can "show dead" in your HN settings.
It isn’t censorship or suppression to delete comments that insult a community and provide nothing constructive to a conversation.
I also don’t care to define what “constructive” is in this context.The HN Mods can handle that.
No there are not. Your account is old enough to have known that there aren't even that many comments at all on this page. IIRC, comments never get deleted, only flagged.
>That the DISC is deeeeeply troubled by the comments on this story should tell you everything you need to know about this topic.
Even accepting your premise of the "DISC" from contrarian podcaster on a wiki with few citations of any claims: No, one little "clue" doesn't tell anyone "everything they need to know" about a topic.
>Speaking of which, is there anything like Snoo for reddit that keeps track of deleted and flagged posts on HN?
I'm not aware of one.