It's a signal that the creator does not want do engage in moderate / discussion on YouTube. There's perfectly valid reasons for that (e.g. topic is controversial, video is only for embedding or archiving on YouTube, there's no social media manager, the video is for kids). It is not a good signal for the video being not worth your time.

Otoh creators can delete comments. So the comments existing and being positive about a video is not a good signal for the video being good either.