TGA files still show up in video game textures surprisingly often
Surprisingly, with PNG, the deflate compression can slow you down, depending on what you are doing with the data. Saving a little bit of IO when you're accessing local data can turn out to be a losing proposition. TGA makes it easier to just shove pixels around, from program to program. TGA has all sorts of weird options which you can ignore, but with PNG, compression is mandatory.