Apologies in advance for the formatting, copied and pasted from YouTube transcript:
https://youtu.be/Xu1FMCxoEFc?t=5928
99:33
But one of the things that came up
99:35
and is a fundamental question that I had,
99:37
that I think probably many of you are asking,
99:38
is does the experience that one has on these compounds
99:43
make a difference for whether or not somebody gains relief
99:46
from depression, from these psilocybin journeys or not?
99:50
In other words, does it matter what they talk about?
99:52
Does it matter what they think about?
99:53
Does it matter if they have a good trip or a bad trip?
99:56
And I don't want to hold you in too much suspense,
99:58
I'll let Matthew provide the more thorough answer.
100:00
But what's really interesting
100:02
is there are some common themes to psilocybin administration
100:08
and experience that lead to relief from depressive symptoms,
100:11
but they are subjectively very varied,
100:17
meaning that whether or not people feel
100:20
they had a good experience or a bad experience,
100:22
whether or not people thought about their parents
100:24
or thought about the color of the ceiling,
100:27
doesn't seem to have too much of an impact
100:30
on whether or not they receive relief
100:32
during these studies in these clinical studies.
100:37
It seems like different people can have
100:38
lots of different experiences and still receive benefit.
100:42
And that points to something deeper.
100:45
It points to the fact that these drugs,
100:48
which is really what they are,
100:49
are rewiring neural circuitry in a common way
100:53
despite a diversity of experience while on the drug.
100:57
And that itself is really interesting.
100:58
And it takes us back to a place that we've been before
101:01
in this discussion, which is layer five of the cortex.
101:04
This area that ketamine seems to impact as well
101:06
by generating rhythms of the,
101:08
I mentioned one to three Hertz activity
101:10
in layer five of certain areas of the cortex.