Spike Protein Goes to Nucleus and Impairs DNA Repair (In-Vitro Study)

Dr Mobeen Syed presents the article

SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro , https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538446/

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Still watching to attempt an abridgement, it will take time. Meanwhile, some provisional bits:

> Researchers from Sweden found the spike protein to be going into the nucleus, and also impairing, reducing, stalling the DNA repair. [...] The study is focused on the vaccines: they said that it is important to maybe not create full spike protein vaccine, instead if you have partial pieces of the spike protein then this whole thing does not happen

> [When] the B cells are making antibodies, when new baby B cells are being made in the bone marrow or the T cells are made in the thymus, they their binding region (the region with which they bind with the antigen) are variable, different for each B cell; that variability is produced by intentionally damaging the DNA and then repairing it, so every time it would form a different shape, and that would give rise to a different variation of the binding region. Now imagine [the immune system's deficiency] if you try to damage [the DNA] and repair [it to] create variations to fight in the immune system, and we could not repair correctly because sars-cov-2 present is stalling and impairing the repair. The authors think that maybe that is the reason that some people cannot actually handle sars-cov-2 well and end up dying.

Interesting that the idea of a Spike protein that is so disruptive, so that the authors of the original article seem to claim that it would be safer to avoid its complete form in vaccines (though the notion that the molecule should not leave the site of injection unless something goes very wrong should put the risks in a relative context), somehow begs to be confronted with the also very recent study with a divulgation article in Nature,

How protein-based Covid vaccines could change the pandemic, https://news.ycombinator.com/item?id=29167908 ,

stating that protein-based Covid vaccines compratively have significantly less side effects and dramatically less severe adverse events associated. Because, while all current relevant vaccines of widespread use are "Spike based", some products in the "subproteic unit" class seem to have tweaked it more. One wonders (the layman wonders) if the use (in some products) of fragments only of the Spike (mentioned in the article) is a cause. (One also wonders how the effects of the Spike can be so relevant if the condition holds that it does not leave the injection site.)

This is covid misinformation. It's always dangerous to extrapolate the results of a study like this to what it means for the vaccine.

For a decent discussion: https://www.reddit.com/r/COVID19/comments/qkq3qp/sarscov2_sp...