OK a one thing that stands out here and please correct me if I'm wrong:
> ... multi-petabyte cluster of Postgres instances... blocksize relatively high at 64 kb ...
The dataset should be the Postgresql "page size" which IIRC is 8KB, the reasoning for this is RMW cycles will read 64kb modify 8KB and write out the full 64KB amplifying writes 8 fold.
Also IIRC Postgresql will automatically use TOAST when needed?