My strategy for dealing with Microsoft's regrettable desktop GUI roadmap is to use the web as much as possible. .NET has an incredible suite of features for pushing functionality to the browser. Kestrel is one of the fastest web servers available today. Developing directly against the AspNetCore pipeline has a bit of a learning curve, but it becomes very intuitive once you get over the DI/startup hard bits, and the performance you can get with low level middleware is staggering (to me).

There are very few applications that simply cannot work in a web browser in 2021. Even accounting for all the inconsistent bullshit between browser vendors, you can still arrive at something that works as far back as IE6 if you are conservative with your footprint.

Do you really need flexbox, webgl2 and GPS navigation for that warehouse inventory management application? Does everything have to live the various app stores? Will your users revolt if there isn't some ceremonial download & install phase of using your product?

I would go so far as to argue for deployment of a self-contained webservice to the end users that could be accessed via any arbitrary localhost browser before succumbing to the Microsoft Desktop GUI framework du jour.