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Comment by swader999 | Hacker News Reader

I had one vaccine dose with severe issues. So maybe I'm skeptical, I won't get a second or third dose. Most people in this camp will just use ivermectin. Including myself, it works and is safe.

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There is no evidence ivermectin works against COVID. There is still one large study running, I think, that might show a small effect, but definitely not a big effect.

Sorry you had a severe issue with your vaccine.

That larger study is only doing three days of doses which unfortunately isn't enough in most cases.

I had a hardened blood clot surgically removed off my scalp the other day. Was in a vein right by my temple. When the report comes back confirming I'm hoping it'll get me a proper scan.

> There is no evidence ivermectin works against COVID

Does that mean that there is no evidence that it doesn't work either? :)

The scientific method generally doesn't prove negatives. In this case, a trial is done where one group is given ivermectin and the other is given sugar pills (placebo). Their health outcomes are compared. If you have enough people in the trial and there is enough of a difference between the outcomes of the 2 groups then you say you have evidence that ivermectin is effective.

The well run trials to this point don't show a significant difference between the groups. The ivermectin advocates say that the trials have not been run correctly for various reasons like dosage, timing, etc. More trials can be run to try to address these concerns. This can be repeated any number of times but at some point people will give up trying if no effect is found.

The antiviral mechanism of Ivermectin involves the inhibition of nuclear transport by importin α/β1 in the host. It can and has lead to death when improperly dosed.

Anything can lead to death when improperly dosed.

The size of dose you are talking about would be only possible to take if you were contemplating suicide.

You left a lot out in regards to the mechanisms of action: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203399/

This article has been retracted 5 months ago. So basically right after publication [1] .

[1] https://pubpeer.com/publications/EDF9109EE29DF2340379B562365...

Yeah it does appear to be a crap article.

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