Anecdotally, hearing from doctors working in COVID wards, they consist almost entirely of anti-vaxxers who are now seeking (and receiving) treatments only recently approved. So while not everyone will take this, I think probably many would once they have symptoms.

That said, this does work better it seems if taken early, before the anti-vax sentiment may have worn off. Hard to say.

What it does signal is really the "end of the pandemic". We have both a vaccine (now approved for kids) and a cure. That sounds like it to me.