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Comment by blip54321 | Hacker News Reader

It does imply that the vaccine would also inhibit DNA damage repair.

I think the key question is timescale. I suspect this would be a short-term side effect, with no real impact. If not -- if it's longitudinal -- it could be scary. I can't imagine how that would happen, though.

Virus would have the same effect, so this isn't an anti-vax argument.

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Yeah, for context I'm fully vaccinated and not trying to create distrust of the mRNA vaccines. Just curious because that seems like a pretty bad thing. It makes sense that this would only happen while the spike proteins are actually present in your body. Thanks for the response!

The mRNA vaccines's mRNA has never been the problem its the adjuvant properties such as the PEG allergies and lipid nanoparticles that have been been causing all the issues. I am sure it will be improved, and they're exploring better adjuvants. When were you vaccinated? If its been a while get your booster. https://www.thelancet.com/journals/lancet/article/PIIS0140-6...

Effectiveness against infections declined from 88% (95% CI 86–89) during the first month after full vaccination to 47% (43–51) after 5 months. Among sequenced infections, vaccine effectiveness against infections of the delta variant was high during the first month after full vaccination (93% [95% CI 85–97]) but declined to 53% [39–65] after 4 months.

Would anything you’ve learned since your first vaccination make you consider “mixing and matching” for reasons other than supply availability?

I did not get vaccinated, I was infected and have antibodies. Pfizer has the least amount of foreign bodies, 30ng vs 100ng from Moderna, the JJ can only be used once, so as long as you are upkeeping boosters you will be fine, but the Moderna vaccine with give a stronger immune response.

I was waiting for Novavax but they kept delaying it constantly (they said summer, then autumn and now 2022), so I am keeping an eye on Medicago as well, since I think the protein subunit ones are hardier than the mRNA ones. Because the studies keep changing (moderna used to be the best, then they said pfizer was just as protective, then during delta they said JJ was good) its hard to predict what problems and which of the vaccines will be best suited to that environment. The best immunity seems to be from a natural infection so a mild infection that creates antibodies has been said to be the best protective (many self reported infections weren't covid, but the ones that had testing showed very protective long lasting effects), although I don't think that its worth it to risk long covid for this effect.

Despite all this, the monoclonal antibody treatment is very good. It is userful post infection or when you are worried about being exposed, its thousands of dollars per treatment (gov paid for it already and it won't cost you), but its something to keep in mind about its usage. The US is buying a lot of them for treatment you may want to make a note of it around you with this site. https://protect-public.hhs.gov/pages/therapeutics-distributi...

Half-life of mRNA is fairly small, as there is no shortage of enzymes that basically just break it down for recycling. The real problem would have to stem from DNA damage that occurred in the presence of the vaccine that did not either lead to cell death, or get repaired later.

>The real problem would have to stem from DNA damage that occurred in the presence of the vaccine that did not either lead to cell death, or get repaired later.

Which is what it sounds like from the title and abstract.

It doesn't cause damage it seems, it impairs repair, so it would have prevented DNA repair during the few days the mRNA would have created spike protein.

I have no idea how often the body needs to repair DNA and what the effects of not doing it for a few days are though.

When you say "the vaccine", do you mean the mRNA vaccines specifically, or all of the vaccines?

It looks like only the mRNA vaccines. That said, the mRNA vaccines seem better at preventing serious COVID cases for longer, so even if they do screw up one's B and T cells, the serious COVID one might catch once one's J&J runs out will screw them up that much more.

From reading the paper, it'd be all of the vaccines, or at least all that build on the spike protein as the target for our immune systems to focus on.

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