Let's set aside what an abject failure the so-called War on Drugs has been in the US and the violence of the drug trade and just appreciate the market economics for a second.
One episode listed all the stages coca leaves took to becoming crack cocaine. Processing in jungle labs, transportation to smugglers, further processing, flying to Mexico, entering the US and distribution. And each stage there is loss to law enforcement, rival gangs, theft, etc and that loss rate is reflected in how the price jumps at each stage.
In another, it detailed how meth (IIRC) entered the US primarily in Phoenix. As a result, Phoenix has (so the show said) the cheapest meth in the US. For every 1000 miles you radiated away from Phoenix, the price doubled.
To me it was fascinating to see people who generally had little education, came from terrible backgrounds and grew up amidst crime and violence talk about the math of distance and price and how it impacted his distribution organization. It's sad to see someone who actually has a talent for hustling and basically sales be lost to the drug world.
This is yet another reason why I think the "are you a felon?" question should basically be outlawed in the US.
Additionally you see how organizations have evolved to insulate themselves from disruption (from rivals or law enforcement). Most people know very little and certainly not the big picture. Merchandise frequently changes hands.
I don't know what the solution here is. I fully support legalization of recreational cannabis in any world where alcohol consumption is legal. I certainly don't think we should be sending people to prison for possession.
At the same time, you have cities like Seattle, Portland and San Francisco that are literally being destroyed by non-policing of drugs and small property crime.
But the US prison industrial complex is and always has been a direct attack on the poor and minorities.