1. go ahead and pull that Ethernet cable, your precious networked daemon will restart thus having to lose whatever cached or learned data. This is a major problem for designer of custom daemons.
2. Try and interface with Juniper DHCP servers at major ISP using systemd-networking and /etc/systemd/network settings. You’ll be forced to revert back to ISC DHCP server and/or NetworkManager.
3. Bootup and actually making your IP-address-senstitive daemon croak because your custom Ethernet NIC requires ‘ip addr/link up’ in /etc/rc.local
4. Bootup and get to network-online state only to find out that your netdev really hasn't gotten a dynamic IP address yet, your networked daemon that requires those IP address to be defined on the netdev will croak if not handled properly.
5. You cannot firewall against PID 1.
For UNIX box that are true server or not cloistered behind an ISP-provided gateway/router, that was more than enough to ditch systemd and go Devuan distro.