it's still true that once you lose a drive you want to pop in a new one and resilver, it just reduces the risk to have 2 spares/parity drives instead of 1.
my array is relatively small and it still takes like 24 hours to resilver one drive. pretty brutal.
my current risk mitigation strategy is to have one spare in the array, and then have one 'warm spare' in the nas that is not part of the array and is instead a target of scheduled backups of the whole array every week. that way if i somehow lose another drive in the array while resilvering is in process i'm not totally screwed. (if my NAS could hold more drives I could do both, but more bays is way more price...)
naturally I also backup to the cloud. but you gotta have a local solution too.