Should the region/counties that have a smaller population but different work forces or geographical makeup not have representation? Population alone cannot dictate the house of representatives.
Part of the problem is that the number of Representatives in the house has been fixed at 435 since the Permanent Apportionment Act of 1929. There would be no "small/rural/unique regions aren't represented without drawing crazy district lines" argument if the number of people represented per US Rep were lower.
And, as we see now, the lines of districts are simply not drawn according to regional peculiar needs. They are drawn by party affiliation, by the parties themselves. Which is insane.