Also not a topologist, but thought it was interesting after watching the video from the current top comment, https://youtu.be/mceaM2_zQd8 , where if you look at the size of the "contained sphere", 4D is the only place where the contained sphere is exactly tangent to the containing box. Lower than that, and it's easy to visualize how the contained sphere is smaller, higher than that, the contained sphere is always bigger. So seems like it might be a natural consequence that techniques that work at higher or lower dimensions don't work for the case in 4D where the sphere is exactly tangent.

The topologist R. H. Bing described it using more colorful language.

> Dimension 4 is the most difficult dimension. It is too old to spank, the way we might deal with the little dimensions 1, 2, and 3; but it is also too young to reason with, the way we deal with the grown-up dimensions 5 and higher.