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Moderna and Pfizer tested variant-specific (B1.351) boosters and found they weren't significantly more-effective than a third dose of the original vaccine. https://www.nature.com/articles/s41591-021-01527-y

This may of course change with new variants.

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>found they weren't more-effective than a third dose of the original vaccine

This goes against the paper:

>A boost with mRNA-1273.351 appeared to be more effective at neutralization of the B.1.351 virus than a boost with mRNA-1273, evidenced by the higher mean GMT levels in the Part C cohort 1 participants (1400) than the GMT Part B participants (864) against the B.1.351 virus. Additionally, the difference between the wild-type and B.1.351 assays at day 1 dropped from 7.7-fold prior to the boost with mRNA-1273.351 to 2.6-fold at 15 days after the boost.

Thank you for posting this though -- I was looking for it earlier for my own comment and couldn't find it! Bookmarking now.

Looking at how this commentary has gone -- why do the worse comments gets get the most traffic? And those with actual data behind them -- zero?

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