As the others have said, it's very difficult to get a H1B, even as a senior. You'd probably have better luck getting a founder visa. No college degree makes it hard to even qualify for a visa; it's literally one of the things they look at.

I've applied to American jobs. I'm told my resume is solid but the conversation stops immediately once I tell them I don't have a work permit there. The only exception were dodgy seed stage companies who had like 9 months runway and no applicants, but even they decided not to go through with it.