The main device life limit for most commercial aircraft is pressurization cycles. The DC-3 is unpressurized, which means that the service lifetime of the airframes is limited mostly by accumulated damage and availability of parts.
The dumbass in me is asking how one breathes safely flying an unpressurized aircraft? Or is it flying at much lower altitude?
https://www.youtube.com/c/MikeyMcBryan/videos
They have their own DC-3 parts inventory. His father discusses buying truckloads of parts at auction back in the day in one video, which are worth 10x now.