I know the imperialists weaponized their diseases and intentionally tried to spread it and that may be the difference.
Usually the smallpox theory is presented in a way that removes agency and culpability from the conquerers. It's always struck me as remarkably convenient and quite unbelievable; they were an idyllic people in some wondrous land without their own disease. Oh really now ... we're talking the Caribbeans here.
Even the Wikipedia page on the matter (https://en.m.wikipedia.org/wiki/Influx_of_disease_in_the_Car...), does it cite epidemiological sources with someone looking at like bone sample DNA? No. It's economic and social science. Excuse me for questioning the qualification of economists for being able to authoritatively make confident statements about historical virology.
It may be true but I'd like more evidence than convenient stories by the descendent of a conquerer about how by sheer coincidence his/her ancestors were actually not guilty of genocide and as of by miracle, North America became a land without people; it just happens to follow Frederick Jackson Turners Frontier Thesis a little too closely to be called a coincidence.