I am pro-vaccination, but agree that vaccine mandates, anti-abortion laws, and other mandates that interfere with bodily autonomy are a violation of fundamental human rights.
On the other hand, most of the ensuing consequences are not a violation of rights, but rather a natural result of any choice that puts others at risk.
Those who are anti-vax for any preventable, deadly disease choose their individual freedom over their community's safety. Such is their right. In turn, it is the right of the community to protect itself against the risk these people introduce.
Anyone may drive their car without a seatbelt on your property, but if they wish to use public roads, they must sacrifice a little bit of individual freedom and wear one.
I can see some logic behind wanting roads to be Local and State responsibilities. It would increase the freedom of individual taxpayers. This might result in a net increase in freedom, despite all the inevitable tolls, unstandardized roadways, and stymied arguments between states over who must pay to restore that crumbling interstate bridge. The economic burden would lift off of the taxpayer's shoulders and fall back on the business or person who uses the roads the most, especially those businesses which have profited from being able to cross state lines efficiently –not something most local folks care to encourage through a federal subsidy anyways. Perhaps the framers of the constitution went too far when they suggested that Congress should be able to tax to, "provide for the common defense and general welfare of the United States...to regulate commerce among the several states...to establish post offices and post roads." Most people don't need packages to go straight to their house anyways!
The same goes for public schools, better referred to as the only school a poor person can afford to attend. Communities should be allowed
But one thing is for sure. If public schools exist as the only option for most of their students, two things are true. First, they cannot stop attendees from being smokers or anti-vaxxers out in the world. Second, they absolutely must restrict these individuals from introducing deadly risks into the classroom.
This is best solved at the State and Local level, but in some cases.
These should never be penalties and restrictions against refusal, but instead protections for the community against the resultant risk. It is for the State and Local government to decide how much they accommodate risk-promoting individuals. For example, many schools are providing separate instruction for anti-vaxxers. Good for those emburdened taxpayers, deciding to help the selfish among them!